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Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response
Authors:Robert Heler  Addison V. Wright  Marija Vucelja  Jennifer A. Doudna  Luciano A. Marraffini
Affiliation:1. Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA;2. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA;3. Department of Physics, University of Virginia, Charlottesville, VA 22904, USA;4. Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA;5. Innovative Genomics Initiative, University of California, Berkeley, Berkeley, CA 94720, USA;6. Center for RNA Systems Biology, University of California, Berkeley, Berkeley, CA 94720, USA;7. Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA;8. Molecular Biophysics & Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA;9. Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
Abstract:
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  • Keywords:CRISPR  Cas9  bacteriophage  immunity  spacer acquisition  staphylococcus
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