Hypomyelination in the Cerebrum of the Congenitally Hypothyroid Mouse (hyt) |
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| Authors: | Tetsuya Noguchi Tetsuro Sugisaki |
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| Institution: | II Department of Physiology, Toho University School of Medicine, Ohmori-nishi, Tokyo, Japan |
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| Abstract: | 2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in the cerebrum of the inherited primary hypothyroid mouse (hyt/hyt) is reduced in comparison with the normal heterozygate (hyt/+). No differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the hypothyroid mouse is restricted to the cerebrum, and is not related to arrested glial proliferation. |
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| Keywords: | Inherited primary hypothyroid mouse (hyt) Hypomyelination 2' 3'-Cyclic nucleotide 3'-phosphohydrolase |
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