Standard free energy maps for the hydrolysis of ATP as a function of pH and metal ion concentration: comparison of metal ions |
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Authors: | K Shikama K I Nakamura |
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Institution: | Biological Institute, Tohoku University, Sendai, Japan |
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Abstract: | The observed equilibrium constant Kobs for the hydrolysis of ATP to ADP and inorganic phosphate has been calculated as a function of pH and metal ion concentration pM (- log M]) at 25 °C and μ = 0.2 with the use of literature values of the acid dissociation and complex dissociation constants for the phosphates.The resulting standard free energy changes ΔG °′ are presented by means of contour diagrams for the range pH 4–10 and pM 1–7. These maps summarize the results of some 1900 calculations per diagram, and clearly simulate a differential effect of the metal ions of interest, including Mg2+, Ca2+, Sr2+, Mn2+, Li+, Na+ and K+, on the equilibrium hydrolysis of ATP. |
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