An Electroacoustic Analysis for Determining the Effect of Amoxicillin on Microbial Cells |
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| Authors: | O I Guliy B D Zaitsev A S Semyonov O S Larionova O A Karavaeva I A Borodina |
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| Institution: | 1.Institute of Biochemistry and Physiology of Plants and Microorganisms,Russian Academy of Sciences,Saratov,Russia;2.Saratov State Vavilov Agrarian University,Saratov,Russia;3.Saratov Branch of Kotel’nikov Institute of Radio Engineering and Electronics,Russian Academy of Sciences,Saratov,Russia |
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| Abstract: | The probability of determining the effects of amoxicillin, which is one of β-lactam antibiotics, on microbial cells of Escherichia coli by the electroacoustic analysis method was shown for the first time. A piezoelectric resonator with a lateral electric field with a 1-mL liquid container was used as a biological sensor. It has been established that in the presence of amoxicillin the frequency dependence of the real and imaginary parts of the electrical impedance of a resonator loaded with a suspension of sensitive cells differs significantly from those of the resonator with a control of a microbial cell suspension without an antibiotic. When the resonator is loaded with the amoxicillin-resistant cell suspension, these dependencies are virtually the same. These results open prospects for the use of electroacoustic analysis methods to register the effect of β-lactam antibiotics on microbial cells and evaluate their antibacterial activity. |
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