Visual cognitive dysfunction in depression: an event-related potential study |
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| Institution: | 1. Pôle de Psychiatrie “Solaris”, Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France;2. Laboratoire de santé publique évaluation des systèmes de soins santé perçue, Université de la Méditerranée, EA 3279, Faculté de Médecine, 27 bd Jean Moulin, 13385 Marseille cedex 05, France;3. Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille, France;4. Services d''explorations fonctionnelles du système nerveux, Clinique du sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France;5. USR CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, France;6. Pole de psychiatrie et d''addictologie des hôpitaux universitaires Henri Mondor, AP-HP, INSERM U955 Eq 15, DHU Pe-Psy, Université Paris-Est Créteil, Fondation Fondamental, France;7. Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université, Site St Charles, 3 place Victor Hugo, 13331 Marseille cedex 3, France;1. University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada;2. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada;3. Department of Psychology, Mount Saint Vincent University, Halifax, Nova Scotia, Canada;4. Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada |
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| Abstract: | The P3(00) event-related potentials (ERPs) elicited by visual stimuli in two visual tasks were assessed in depressed patients (12 patients with major depression and 11 patients with bipolar disorder) and compared with those of 20 age-matched normal controls. At remission, the ERPs from 18 of the depressed patients were again recorded. The visual oddball (VO) paradigm presented both target and standard visual stimuli and the simple visual (SV) paradigm presented a target but no standard visual stimulus. Subjects performed the VO task significantly less accurately than the SV task, as reflected by the behavioral measures (reaction-time and task accuracy). Depressed patients of the bipolar group showed longer P3 peak latency for the VO task and no change in P3 amplitude. No significant differences were found in any other ERP component between the groups. During remission, slowing RTs and reduced P3 peak latencies were observed for both major depression and bipolar disorder groups. Thus, the P3 ERP may be an index of the contribution of the slowed central processing to psychomotor retardation in clinically homogenous samples of depressive patients performing an appropriately demanding task. |
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