Emerging roles of PHLPP phosphatases in metabolism |
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| Authors: | Jong-Ho Cha Yelin Jeong Ah-Reum Oh Sang Bae Lee Soon-Sun Hong KyeongJin Kim |
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| Affiliation: | 1.Department of Biomedical Sciences, College of Medicine, Inha University, Incheon 22212, Korea;2.Program in Biomedical Science & Engineering, Inha University, Incheon 22212, Korea;3.Research Center for Controlling Intercellular Communication (RCIC), College of Medicine, Inha University, Incheon 22212, Korea;4.Division of Life Sciences, Jeonbuk National University; Sarcopenia Total Solution Center, Jeonju 54896, Korea |
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| Abstract: | Over the last decades, research has focused on the role of pleckstrin homology (PH) domain leucine-rich repeat protein phosphatases (PHLPPs) in regulating cellular signaling via PI3K/Akt inhibition. The PKB/Akt signaling imbalances are associated with a variety of illnesses, including various types of cancer, inflammatory response, insulin resistance, and diabetes, demonstrating the relevance of PHLPPs in the prevention of diseases. Furthermore, identification of novel substrates of PHLPPs unveils their role as a critical mediator in various cellular processes. Recently, researchers have explored the increasing complexity of signaling networks involving PHLPPs whereby relevant information of PHLPPs in metabolic diseases was obtained. In this review, we discuss the current knowledge of PHLPPs on the well-known substrates and metabolic regulation, especially in liver, pancreatic beta cell, adipose tissue, and skeletal muscle in relation with the stated diseases. Understanding the context-dependent functions of PHLPPs can lead to a promising treatment strategy for several kinds of metabolic diseases. |
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| Keywords: | Metabolic diseases PHLPP1 PHLPP2 Substrates |
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