Activation of glyoxalase I during the cell division cycle and its homology with auxin regulated genes |
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| Institution: | 1. UCIBIO/REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal;2. Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal;3. Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal;4. Departamento de Biologia Molecular, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal;5. Cell Death Regulation Laboratory, MRC Toxicology Unit, Leicester, United Kingdom;1. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA;2. Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA |
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| Abstract: | In several plant systems increase in glyoxalase I activity has been correlated with cell proliferation. Cell cycle studies of tobacco protoplasts indicate a rise in glyoxalase I activity prior to G2/M phase. Further, synthetic auxin, NAA, induced glyoxalase I activity and cell division significantly. This induction was specific in response to auxin only. Cytokinins alone do not induce cell division or increase enzyme activity. Analysis of glyoxalase I cDNA sequence from soybean shows significant homology with auxin inducible genes particularly Nt107 and limited but strong similarity with identified plant mitotic cyclins, implicating glyoxalase I in possible relationship with certain cell division regulating factors. |
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