Signal transduction via platelet-derived growth factor receptors |
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| Affiliation: | 2. Translational Medical Center, Xiamen University, Xiamen, People’s Republic of China;1. Department of Pharmacy, Huashan Hospital North, Shanghai 201907, China;2. Department of General Surgery, Huashan Hospital North, Shanghai 201907, China;3. Department of Cardio-thoracic surgery, Huashan Hospital, Shanghai 200040, China;4. Brunswick Laboratories (China), Suzhou Industrial Park 215021, China;5. Pharmacy Department, Xuhui district Central Hospital, 966 Huai Hai M Road, Shanghai 200031, China;6. School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, China |
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| Abstract: | Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic SH2-domain containing signal transduction molecules. Thereby, a number of different signaling pathways are initiated leading to cell growth, actin reorganization migration and differentiation. Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel. |
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