Peptide nucleic acids: deoxyribonucleic acid mimics with a peptide backbone |
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| Institution: | 1. Institute for Superconducting and Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, North Wollongong, NSW 2500, Australia;2. Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia;1. School of Chemical Engineering, University of Science and Technology Liaoning, 185 Qianshan Zhong Road, Gaoxin District, Anshan 114051, Liaoning, China;2. State Key Laboratory of Fine Chemicals, Carbon Research Laboratory, School of Chemical Engineering, Dalian University of Technology, Dalian 116012, Liaoning, China |
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| Abstract: | This tutorial briefly describes a new class of synthetic biopolymer, which is referred to as peptide nucleic acid (PNA). In PNA, individual nucleobases are linked to an achiral neutral peptide backbone. PNA exhibits the hybridization characteristic (e.g., Watson—Crick duplex formation) of DNA. The achiral peptide backbone provides similar interbase distances as natural DNA, and adequate flexibility to permit base pair interactions with complementary RNA or DNA strands. Several potential applications of PNA oligomers in biotechnology are suggested. These include the use of PNAs as a probe for specific recognition of a DNA or RNA sequence selective, purification of nucleic acids via designed high affinity binding to PNA, screening for DNA mutations, and as possible therapeutic agents. |
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