Stimulation of cell proliferation by vitamin A derivatives on murine sarcoma virus-transformed mouse cells in serum-free culture |
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Authors: | A Hiragun M Sato H Mitsui |
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Affiliation: | Department of Pharmacology, Hebrew University-Hadassah Medical School, Jerusalem 91010, Israel |
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Abstract: | The effect of retinoids (Rds) on cell proliferation was studied in serum-free culture condition, using non-transformed and transformed derivatives of BALB 3T3. Cell proliferation of an SV40-transformed line was inhibited significantly by Rd treatment. However, proliferation of two cell lines that were transformed by a Kirsten and Moloney strain of murine sarcoma virus (MSV) and produced growth factor into culture medium, was remarkably stimulated by Rds. Addition of serum masked both the inhibitory and stimulatory effects of Rds. |
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Keywords: | To whom offprint requests should be sent. Address: Yale University School Medicine. Department of Ophthalmology & Visual Science New Haven CT 06510 USA. |
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