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Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients |
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| Authors: | Leonardo Barrios María Rosa Caballín Rosa Mirò Carme Fuster Georgina Berrozpe Antoni Subías Xavier Batlle Josep Egozcue |
| Institution: | (1) Department de Biologia Cel.lular i Fisiologia, Universitat Autònoma de Barcelona, E-08 193 Bellaterra (Barcelona), Spain;(2) Institut de Biologia Fonamental  Vicent Villar Palasi , Universitat Autònoma de Barcelona, E-08 193 Bellaterra (Barcelona), Spain;(3) Departament de Biologia Animal Vegetal i Ecologia, Universitat Autònoma de Barcelona, E-08 193 Bellaterra (Barcelona), Spain;(4) Servei d'Oncologia, Hospital de la Santa Creu i Sant Pau, E-08025 Barcelona, Spain |
| Abstract: | Summary We describe the presence of a high frequency of spontaneous chromosome aberrations in lymphocytes from six untreated patients with Hodgkin's disease. The characteristics of the chromosome abnormalities observed suggest the existence of a certain degree of chromosome instability in these cases, that could be a predisposing factor for the development of malignancies. |
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