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Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth |
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| Authors: | Janecka Anna Fichna Jakub Kosson Piotr Zalewska-Kaszubska Jadwiga Krajewska Urszula Mirowski Marek Rozalski Marek |
| Institution: | a Department of Medicinal Chemistry, Medical University, Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland b Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland c Department of Pharmacodynamics, Medical University, Lodz, Poland d Department of Pharmaceutical Biochemistry, Medical University, Lodz, Poland |
| Abstract: | In the present study, we reported on the synthesis of two new mu-opioid peptide analogs, D-1-Nal3]morphiceptin and D-1-Nal4]-morphiceptin 1-Nal=3-(1-naphthyl)-alanine] which expressed receptor binding affinities at least at the level of the primary opioid ligands. The new analogs also labeled mu-opioid receptors on the cells of human breast cancer MCF-7 cell line with affinity much higher than that of endomorphins and morphiceptin, the well-known mu-selective opioid peptides. However, none of the tested peptides significantly decreased cell proliferation of MCF-7 cells. |
| Keywords: | Morphiceptin Endomorphin-1 and -2 Peptide analogs Antiproliferative effects Binding studies |
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