Control of secretory granule interaction and exocytosis in pancreatic cells |
| |
Authors: | E. K. Matthews Jane Rogers D. B. McKay |
| |
Affiliation: | (1) Department of Pharmacology, University of Cambridge, Hills Road, CB2 2QD Cambridge |
| |
Abstract: | Application of the laser-based technique of photon correlation spectroscopy to anin vitro study of the ionic stability and interaction kinetics of zymogen granules isolated from rat exocrine pancreas is described here. In addition the separation from pancreatic acinar cell cytosol of a factor which stabilizes isolated zymogen granules and inhibits cation-induced granule aggregation is outlined. The basis of this action and the significance of the cytosolic inhibitory factor in the regulation of granule mobility and exocytosisin vivo is discussed. |
| |
Keywords: | photon correlation spectroscopy exocrine pancreas exocytosis zymogen granules |
本文献已被 SpringerLink 等数据库收录! |