In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent |
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Authors: | Yamamoto Tatsuhiro Ikuta Kenjiro Oi Keiji Abe Kohtaro Uwatoku Toyokazu Hyodo Fuminori Murata Masaharu Shigetani Noboru Yoshimitsu Kengo Shimokawa Hiroaki Utsumi Hideo Katayama Yoshiki |
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Affiliation: | Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan. |
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Abstract: | A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases. |
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