A recombinant antigen recognized by Fasciola hepatica-infected hosts |
| |
Authors: | Silva Elisabete Castro Antonio Lopes António Rodrigues Artur Dias César Conceição Antónia Alonso José Correia da Costa J M Bastos Maria Parra Francisco Moradas-Ferreira Pedro Silva Maria |
| |
Institution: | Laboratório de Parasitologia, Centro de Imunologia e Biologia Parasitária, Instituto Nacional de Saúde Dr. Ricardo Jorge do Porto, Rua de S?o Luís N(o) 16, 4000-509 Porto, Portugal. |
| |
Abstract: | This work reports the detection of specific immunoglobulins (Ig) against rFh8, a recombinant Fasciola hepatica adult worm excretion-secretion antigen, in sera from experimentally (rabbit, Wistar rat, cattle, and sheep), or naturally (human) infected hosts. In the case of laboratory experimental models the study revealed significant differences between rabbits, which recognized the recombinant antigen all along the infection, and Wistar rats, which showed high anti-rFh8 Ig levels only for a short period of the infection. Available sera from experimentally infected cattle and sheep, as well as sera from naturally F. hepatica-infected humans, also contained significant levels of Ig against rFh8, suggesting that Fh8 was produced by F. hepatica at a very early stage of infection in all hosts so far analyzed and that the rFh8 antigen could be used as a tool for the diagnosis of F. hepatica infections. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|