Radioimmunoassay of urinary 21-deoxytetrahydroaldosterone in primary aldosteronism and 21-hydroxylase deficiency |
| |
| Authors: | S Lewicka J Winter V D Bokkenheuser P Vecsei S Abdelhamid U Heinrich |
| |
| Institution: | 1. Department of Pharmacology, University of Heidelberg, 6900 Heidelberg, F.R.G.;3. Department of Pathology, St Luke''s-Roosevelt Hospital Center, New York, U.S.A.;4. Deutsche Klinik für Diagnostik, Wiesbaden, F.R.G.;5. Department of Pediatrics, University of Heidelberg, Heidelberg, F.R.G.;1. Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain;2. Instituto de Investigación Sanitaria del Principado de Asturias (ISPA) [Health Research Institute of Asturias], Oviedo, Spain;3. Department of Medicine, University of Oviedo, Spain;4. Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III [Carlos III Health Institute], Madrid, Spain;1. Servicio de Endocrinología y Nutrición, Hospital Universitario La Paz, Madrid, Spain;2. Servicio de Endocrinología y Nutrición, Hospital Universitario Clínico San Carlos, Madrid, Spain;3. Servicio de Endocrinología y Nutrición, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain;4. Servicio de Endocrinología y Nutrición, Complejo Universitario Hospitalario de Albacete, Albacete, Spain;5. Servicio de Endocrinología y Nutrición, Hospital Clínic, Universidad de Barcelona, IDIBAPS, Barcelona, Spain;6. Servicio de Endocrinología y Nutrición, Hospital Universitario Ramón y Cajal, Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Departamento de Ciencias de la Salud, Universidad Alcalá, Madrid, Spain |
| |
| Abstract: | A radioimmunoassay of 21-deoxytetrahydroaldosterone was developed. Normal daily excretion of the unconjugated metabolite was 1.2 +/- 1.3 micrograms and of the glucuronized metabolite, 11.9 +/- 7 micrograms. The tetrahydroaldosterone/21-deoxytetrahydroaldosterone ratio varied more in patients with primary aldosteronism than in control subjects. Thus, measurements of the urinary excretion of the tetrahydroaldosterone or 21-deoxytetrahydroaldosterone alone did not provide an accurate expression for aldosterone production. Their sum correlated well with the clinical condition, i.e. clear-cut elevation in patients with primary aldosteronism. The diminished tetrahydroaldosterone/21-deoxytetrahydroaldosterone ratio found in patients with 21-hydroxylase deficiency may be attributed to increased bacterial conversion of tetrahydroaldosterone to 21-deoxytetrahydroaldosterone but could also stem from a deficiency implicating zona glomerulosa (aldosterone biosynthesis) regardless of the stage and clinical presentation of the disease. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
