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A model for cleavage ofO-glycosidic bonds in glycoproteins |
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| Authors: | Farid M Ibatullin Alexander M Golubev Leonid M Firsov Kirill N Neustroev |
| Institution: | (1) Department of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Gatchina, 188 350 St Petersburg, Russia |
| Abstract: | The present work investigated the possibility of cleavage of  -linkages between mannose or galactose and serine/threonine residues by -mannosidase and -galactosidase. The study was carried out initially with model synthetic compounds imitating theO-glycosidic bond in glycoproteins, and further with glucoamylase. It was shown that -mannosidase and -galactosidase can hydrolyse these linkages after proteolytic digestion of glucosamylase. |
| Keywords: | O-glycoprotein glucoamylase |
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