| 人正常软骨和软骨肉瘤蛋白多糖的比较研究 |
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| 引用本文： | 薛延,屠德康,褚为靖,贾维维,于小鹏,宋钰,于志坚,徐万鹏,蔡槱伯,乐守玉,吴大东. 人正常软骨和软骨肉瘤蛋白多糖的比较研究[J]. 中国生物化学与分子生物学报, 1988, 4(5): 432-438 |
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| 作者姓名： | 薛延 屠德康 褚为靖 贾维维 于小鹏 宋钰 于志坚 徐万鹏 蔡槱伯 乐守玉 吴大东 |
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| 作者单位： | 北京市创伤骨科研究所生化研究室(薛延，屠德康，褚为靖，贾维维，于小鹏，宋钰，于志坚)，北京积水潭医院骨科(徐万鹏，蔡槱伯，乐守玉)，北京积水潭医院骨科(吴大东) |
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| 摘 要： | 取三例一般型一级的软骨肉瘤及不同年令正常人股骨头关节软骨,经4mol/L盐酸胍提取和氯化铯平衡等密度梯度离心,分析蛋白多糖组份的化学组成,并用Sepharose CL-2B层析分析蛋白多糖分子大小。初步结果,两例软骨肉瘤蛋白多糖的化学组成和分子大小与新生儿接近,另一例软骨肉瘤蛋白多糖的化学组成和分子大小与成年人相似。此结果说明软骨肉瘤生物学行为的多变性及其蛋白多糖的异质性。
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| 关 键 词： | 蛋白多糖 糖胺多糖 硫酸软骨素 硫酸角质素 |
| 收稿时间： | 1988-10-20 |
A COMPARATIVE STUDY ON THE PROTEOG-LYCANS OF HUMAN NORMAL AND NEOPLASTIC CARTILAGE |
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| Xue,Yan Tu,De-Kong Chu,Wei-jing Jia,Wei-wei Yu,Xiao-penSong,Yu Yu,Zhi-jian. A COMPARATIVE STUDY ON THE PROTEOG-LYCANS OF HUMAN NORMAL AND NEOPLASTIC CARTILAGE[J]. Chinese Journal of Biochemistry and Molecular Biology, 1988, 4(5): 432-438 |
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| Authors: | Xue Yan Tu De-Kong Chu Wei-jing Jia Wei-wei Yu Xiao-penSong Yu Yu Zhi-jian |
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| Affiliation: | (Laboratory of Biochemistry, Beijing Research Institute of Traumatology and Orthopedics)Xu, Wan-peng Cai, You-be Yue, Shou-yu Wu, Da- dung (Department of Orthopedics, Beijing Ji Shui Tan Hospital |
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| Abstract: | Proteoglycans from three cases of low-grade chondrosarcoma (A,B and C) and normal articular cartilage (femoral head) of dif frent ages were compared. Proteo-glycan (PG) subunit was extracted by 4mol/L Gu.HCI and isolated by CsCI-density-gra-dient centrf ugation and analysed by sepharose CL-2B chromatography. The results showed that the chemical composition and the size of PG subunit from chondrosarcoma A and B were indicative of immaturity and those from chondrosarcoma C were similar to those from mature articular cartilage.The data presented indicate that the cartilage tumors have remarkable variability of biological behavior and heterogeneity of proteoglycans. |
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| Keywords: | proteoglycans glycosaminoglycan chondroitin sulphate Keratan sulphate |
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