lncRNAs在心血管疾病发生中的作用

长链非编码RNA（long noncoding RNAs, lncRNAs）可以在多个阶段干扰基因表达和信号途径。在心血管系统，内皮表达的lncRNAs，如MALAT1和Tie 1 AS可以调节血管生长和功能。平滑肌细胞和内皮细胞中富含的迁移或分化相关的lncRNAs可调控平滑肌细胞收缩表型。在严重心肌梗塞和心衰时，一些lncRNAs表达水平发生调节，如Novlnc6和Nhrt。还有一些lncRNAs参与调节心肌细胞肥大、线粒体功能和心肌细胞凋亡。本文总结了lncRNA在心血管疾病中的研究进展，期待为更有效的治疗心血管疾病开发新的方向。

Roles of LncRNAs in the Occurrence of Cardiovascular Diseases

In recent years, increasing evidence suggests that long noncoding RNAs (lncRNAs) can interfere with expression of genes and signaling pathways at various stages. In the cardiovascular system, the endothelial-expressed lncRNAs (eg, MALAT1 and Tie-1-AS) can regulate vessel growth and function, whereas smooth muscle and endothelial cell enriched migration/differentiation associated lncRNAs were showed to control the contractile phenotype of smooth muscle cells. Levels of several lncRNAs are regulated during acute myocardial infarction (eg, Novlnc6) and heart failure (eg, Mhrt). Additionally, some lncRNAs are involved in regulation of hypertrophy, mitochondrial function and apoptosis of cardiomyocytes. This review summarizes the latest progress on the investigation of lncRNAs in cardiovascular diseases and highlights identified cardiovascular lncRNAs that might play a role in cardiovascular diseases.