Hibernation-related changes in the immunoreactivity of neuropeptide systems in the suprachiasmatic nucleus of the ground squirrel,Spermophilus richardsonii |
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Authors: | Christoph U Schindler Frank Nürnberger |
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Institution: | (1) Department of Anatomy and Cytobiology, Justus Liebig University, Giessen, Federal Republic of Germany;(2) Department of Anatomy and Cytobiology, Aulweg 123, D-6300 Giessen, FRG |
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Abstract: | Summary The pattern of distribution and reactivity of the neuropeptides vasopressin (AVP), vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), substance P (SP), and thyrotropin-releasing hormone (TRH) were studied in the suprachiasmatic nucleus (NSC) of 20 Richardson's ground squirrels (and 7 European hedgehogs) of both sexes during hibernation and euthermia. The total area of immunostained structures revealed by application of the individual immunocytochemical techniques was measured by means of computer-aided image analysis. In both species, elements of all peptide systems examined were related to particular subdivisions of the NSC. The pattern of immunoreactivity was strongly correlated with the physiological stage of hibernation or euthermia both in ground squirrels and hedgehogs. The immunoreactivities to AVP and SP increased in area during hibernation (AVP: 25%; SP: 25%), whereas the respective area immunoreactive to NPY and VIP decreased (NPY: 45%; VIP: 100%) in comparison to nonhibernating controls. The TRH-immunoreactive nerve fibers were rare and rather scattered; thus, the quantitative procedure was not applicable for this immunoreaction.Abbreviations
AVP
argnine vasopressin
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NPY
neuropeptide Y
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NSC
suprachiasmatic nucleus
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SP
substance P
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TRH
thyrotropinreleasing hormone
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VIP
vasoactive intestinal peptide
The results have been partly presented at the 10th International Symposium on Neurosecretion held in Bristol, UK, September 1987 |
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Keywords: | Suprachiasmatic nucleus Neuropeptide immunocytochemistry Image analysis Neuropeptide Y Substance P Thyrotropin-releasing hormone Vasoactive intestinal peptide Vasopressin Spermophilus richardsonii (Rodentia) Erinaceus europaeus (Insectivora) |
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