Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection |
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Authors: | Bowen David G Shoukry Naglaa H Grakoui Arash Fuller Michael J Cawthon Andrew G Dong Christine Hasselschwert Dana L Brasky Kathleen M Freeman Gordon J Seth Nilufer P Wucherpfennig Kai W Houghton Michael Walker Christopher M |
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Institution: | Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, 700 Childrens Dr., Columbus, OH 43205, USA. |
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Abstract: | The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections. |
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