Pharmacological activity of PGI2 and its metabolite 6-OXO-PGF1α on human uterus and fallopian tubes |
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| Authors: | Omini C Pasargiklian R Foloc GC Fano M Berti F |
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| Institution: | 1. Institute of Pharmacology and Pharmacognosy, School of Pharmacy, University of Milan, 20129 Milan, Italy;1. II^ Clinic of Obstetric and Gynecology, School of Medicine, University of Milan, 20100 Milan, Italy |
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| Abstract: | The actions of prostacyclin (PGI2) and its stable metabolite 6-OXO-PGF1α were investigated in strips of normal human uterus and in fallopian tubes.Both compounds were also compared with natural prostaglandins (PGE2, PGF2α and PGD2).PGI2 showed biphasic response both in uterus and fallopian tubes qualitatively and quantitatively similar to that induced by PGE2 and PGD2; prostacyclin was also able to inhibit the spasmus induced by PGF2α but not that induced by BaCl2 and vasopressin.6-OXO-PGF1α on the other hand induced only small contractions on both tissues investigated.The authors discusse the possible implication of these findings in the physiology of the reproductive system. |
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