Lobelane analogues as novel ligands for the vesicular monoamine transporter-2 |
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| Authors: | Zheng Guangrong Dwoskin Linda P Deaciuc Agripina G Zhu Jun Jones Marlon D Crooks Peter A |
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| Institution: | College of Pharmacy, University of Kentucky, Rose Street, Lexington, KY 40536-0082, USA. |
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| Abstract: | A series of lobelane analogues has been synthesized and their structure-activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with K(i) values ranging from 430 to 580 nM. |
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