Theiler's virus L protein is targeted to the mitochondrial outer membrane |
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Authors: | Sorgeloos Frédéric Vertommen Didier Rider Mark H Michiels Thomas |
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Affiliation: | Université Catholique de Louvain, de Duve Institute, MIPA-VIRO 74-49, 74 Avenue Hippocrate, B-1200 Brussels, Belgium,1 Université Catholique de Louvain, de Duve Institute, HORM-PHOS 75-29, 75 Avenue Hippocrate, B-1200 Brussels, Belgium2 |
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Abstract: | The L protein encoded by Theiler's murine encephalomyelitis virus (TMEV) is a unique example of a picornaviral protein encoded by an alternative open reading frame. This protein is an important determinant of TMEV persistence in the mouse central nervous system. We showed that in infected cells, L is partitioned between the cytosol and the mitochondria. In mitochondria, L is anchored in the outer membrane and exposed to the cytosol. The targeting of L to mitochondria is independent of other viral components and likely depends on a conformational signal. L targeting to mitochondria might involve chaperones of the Hsp70 family, as these proteins are shown to interact. |
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