Aberrant breakpoints in chronic myelogenous leukaemia; oncogenes and fragile sites |
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Authors: | J L Huret J Tanzer M Henry-Amar |
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Institution: | (1) Département d'Hématologie et Oncologie Médicale, Hôpital Jean Bernard, F-86021 Poitiers Cedex, France;(2) Département de Statistique Médicale, Institut Gustave Roussy, F-94805 Villejuif Cedex, France;(3) Centre de Transfusion Sanguine, F-86021 Poitiers, France |
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Abstract: | Summary Three hundred and twenty-five aberrant breakpoints in chronic myelogenous leukaemia (CML) with Philadelphia chromosome variant were reviewed. Eight chromosomal bands (3p21, 6p21, 7p22, 11q13, 12p13, 17p13, 17q21, and 17q25) were found to be highly involved. Apart from 17q25, all these bands correspond to oncogenes sites and/or sites involved as primary breakpoints in cancer.This work was presented in part at the Congrès National d'Hématologie et de Transfusion Sanguine, March 1985 (Nouv Rev Fr Hématol, 1985, 27:72) and at the American Association for Cancer Research Meeting (Proceeding of the AACR 1986, 27:148) |
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