Metabolic compartmentation in African trypanosomes |
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| Authors: | Clayton C E Michels P |
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| Affiliation: | 1. Zentrum für Molekulare Biologie, Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany;2. International Institute of Cellular and Molecular Pathology, and Laboratoire de Chimie Physiologique, Université Catholique de Louvain, Brussels, Belgium;1. Laboratory of Oceanology, MARE Centre, University of LIEGE, B6C, 4000 LIEGE, Sart Tilman, Belgium;2. Institute of Marine Sciences, University of Portsmouth, Ferry Road, Portsmouth PO4 9LY, United Kingdom;3. FRES 3041, EqEL, University of Corsica, Faculty of Sciences, BP 52, 20250 Corte, France;4. UMR 241 EIO, University of French Polynesia, BP 6570, 98 702 Faa''a, Tahiti, French Polynesia;1. Erciyes University, Faculty of Engineering, Department of Food Engineering, 38039, Kayseri, Turkey;2. Yildiz Technical University, Faculty of Chemical and Metallurgical Engineering, Department of Food Engineering, 34210 Istanbul, Turkey;3. Yildiz Technical University, Faculty of Electrical-Electronics Engineering, 34210 Istanbul, Turkey |
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| Abstract: | Differences between host and parasite energy metabolism are eagerly sought after as potential targets for antiparasite chemotherapy. In Kinetoplastia, the first seven steps of glycolysis are compartmented inside glycosomes, organelles that are related to the peroxisomes of higher eukaryotes. This arrangement is unique in the living world. In this review, Christine Clayton and Paul Michels discuss the implications of this unusual metabolic compartmentation for the regulation of trypanosome energy metabolism, and describe how an adequate supply of energy is maintained in different species and life cycle stages. |
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