Effects and mechanisms of action of sildenafil citrate in human chorionic arteries |
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| Authors: | Chrisen H Maharaj Daniel O'Toole Tadhg Lynch John Carney James Jarman Brendan D Higgins John J Morrison John G Laffey |
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| Institution: | (1) Department of Anaesthesia, University College Hospital, Galway, Ireland;(2) Department of Anaesthesia, Clinical Sciences Institute and National Centre for Biomedical Engineering Sciences, National University of Ireland, Galway, Ireland;(3) Department of Obstetrics and Gynaecology, Clinical Sciences Institute, National University of Ireland, Galway, Ireland |
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| Abstract: | Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy.
Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for premature
labor. Its effects in the feto-placental circulation are not known. Our objectives were to determine whether phosphodiesterase-5
is present in the human feto-placental circulation, and to characterize the effects and mechanisms of action of sildenafil
citrate in this circulation. |
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