|
|||||
|
|
The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders |
|
| Authors: | Takuro Furusawa Izumi Naka Taro Yamauchi Kazumi Natsuhara Ryosuke Kimura Minato Nakazawa Takafumi Ishida Tsukasa Inaoka Yasuhiro Matsumura Yuji Ataka Nao Nishida Naoyuki Tsuchiya Ryutaro Ohtsuka Jun Ohashi |
| Affiliation: | 1. Asian Studies Network (ASNET), Division for International Relations, The University of Tokyo, Tokyo, Japan 2. Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan 3. Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan 4. School of Nursing, Fukuoka Prefectural University, Fukuoka, Japan 5. Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan 6. Department of Public Health, Graduate School of Medical Sciences, Gunma University, Gunma, Japan 7. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan 8. Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan 9. Faculty of Health Care, Kiryu University, Gunma, Japan 10. School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan 11. Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 12. Japan Wildlife Research Center, Tokyo, Japan |
| Abstract: | Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI ≥ 30) in Pacific Islanders. A total of 745 Austronesian (AN)-speaking participants were analyzed after adjusting for age, gender, and population differences. The results revealed that carriers of the 223Q alleles of LEPR had significantly higher body weight (P = 0.0009) and BMI (P = 0.0022) than non-carriers (i.e., 223R homozygotes); furthermore, the 223Q carriers also had a significantly higher risk of obesity in comparison to non-carriers (P = 0.0222). The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity. The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |