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The overexpression of major antioxidant enzymes does not extend the lifespan of mice |
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| Authors: | Viviana I Pérez Holly Van Remmen Alex Bokov Charles J Epstein Jan Vijg Arlan Richardson |
| Institution: | Barshop Institute for Longevity and Aging Studies,;Department of Cellular and Structural Biology,;Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA; Institute of Human Genetics and;Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA |
| Abstract: | We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice. |
| Keywords: | aging antioxidant enzymes transgenic and knockout mice |