Systems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase |
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| Authors: | Kaspar Valgepea Kaarel Adamberg Ranno Nahku Petri-Jaan Lahtvee Liisa Arike Raivo Vilu |
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| Affiliation: | 1.Tallinn University of Technology, Department of Chemistry,Tallinn,Estonia;2.Competence Centre of Food and Fermentation Technologies,Tallinn,Estonia;3.Department of Food Processing,Tallinn University of Technology,Tallinn,Estonia |
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| Abstract: | Background The biotechnology industry has extensively exploited Escherichia coli for producing recombinant proteins, biofuels etc. However, high growth rate aerobic E. coli cultivations are accompanied by acetate excretion i.e. overflow metabolism which is harmful as it inhibits growth, diverts valuable carbon from biomass formation and is detrimental for target product synthesis. Although overflow metabolism has been studied for decades, its regulation mechanisms still remain unclear. |
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