Cellular and molecular evidence for a role of tumor necrosis factor alpha in the ovulatory mechanism of trout |
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| Authors: | Diego Crespo Emilie Bonnet Nerea Roher Simon A MacKenzie Aleksei Krasnov Frederick W Goetz Julien Bobe Josep V Planas |
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| Affiliation: | 1.Departament de Fisiologia, Facultat de Biologia,Universitat de Barcelona and Institut de Biomedicina de la Universitat de Barcelona (IBUB),Barcelona,Spain;2.Institut National de la Recherche Agronomique (INRA), UR1037 SCRIBE, IFR140,Campus de Beaulieu,Rennes,France;3.Unitat de Fisiologia Animal,Departament de Biologia Cellular, Fisiologia i d'Immunologia, Facultat de Ciències, Universitat Autònoma de Barcelona (UAB),Spain;4.Nofima Akvaforsk Fiskeriforskning AS,Norway;5.Great Lakes Water Institute,University of Wisconsin-Milwaukee,Wisconsin,USA |
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| Abstract: | Background The relevance of immune-endocrine interactions to the regulation of ovarian function in teleosts is virtually unexplored. As part of the innate immune response during infection, a number of cytokines such as tumor necrosis factor alpha (TNF alpha) and other immune factors, are produced and act on the reproductive system. However, TNF alpha is also an important physiological player in the ovulatory process in mammals. In the present study, we have examined for the first time the effects of TNF alpha in vitro in preovulatory ovarian follicles of a teleost fish, the brown trout (Salmo trutta). |
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