Localization, analysis and evolution of transposed human immunoglobulin V kappa genes |
| |
Authors: | E L?tscher F J Zimmer T Klopstock K H Grzeschik R Jaenichen B Straubinger H G Zachau |
| |
Affiliation: | Institut für Physiologische Chemie, Universit?t München, F.R.G. |
| |
Abstract: | The localization of V kappa gene regions to chromosome 2, on which the kappa locus is located, and to other chromosomes is described. The V kappa genes that have been transposed to other chromosomes are called orphons. The finding of two new V kappa genes on chromosome 22 is reported. A V kappa II gene of this region and two V kappa I genes of the Chr1 and the cos 118 regions were sequenced. The two V kappa I orphon sequences and two others that had been determined previously were 97.5% identical, indicating that they may have evolved from a common ancestor by amplification. A model of the evolution of the human V kappa orphons is discussed. |
| |
Keywords: | |
|
|