| 宏基因组学技术的研究与挑战 |
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| 引用本文： | 周丹燕,戴世鲲,王广华,李翔. 宏基因组学技术的研究与挑战[J]. 微生物学通报, 2011, 38(4): 591-600 |
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| 作者姓名： | 周丹燕 戴世鲲 王广华 李翔 |
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| 作者单位： | 1. 中国科学院南海海洋研究所海洋生物资源可持续利用重点实验室,广东省海洋药物重点实验室,广东,广州,510301;中国科学院研究生院,北京,100049
2. 中国科学院南海海洋研究所海洋生物资源可持续利用重点实验室,广东省海洋药物重点实验室,广东,广州,510301 |
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| 基金项目： | 国家973计划项目(No. 2010CB833801-03); 大洋协会项目课题(No. DYXM-115-02-2-14); 广东省科技计划项目(No. 2008A030203004) |
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| 摘 要： | 宏基因组学研究作为研究微生物种群生态分布、群体遗传特征和基因相互作用的新兴学科领域,在很大程度上促进了环境微生物资源,特别是未培养微生物资源的开发利用,在土壤、海洋、人体医学、药物等各个领域的应用中取得了突破性的进展,为发现新的生物活性物质提供了新的有效途径。就宏基因组学研究进展进行综述,并重点介绍了宏基因组学研究中的机遇及挑战。
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| 关 键 词： | 宏基因组学 宏基因组文库 序列筛选 功能筛选 新一代测序 |
The research innovation and challenges in metagenomics |
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| ZHOU Dan-Yan,DAI Shi-Kun,WANG Guang-Hua and LI Xiang. The research innovation and challenges in metagenomics[J]. Microbiology China, 2011, 38(4): 591-600 |
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| Authors: | ZHOU Dan-Yan DAI Shi-Kun WANG Guang-Hua LI Xiang |
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| Affiliation: | 1. Key Laboratory of Marine Bio-resources Sustainable Utilization, Key Laboratory of Marine Drug, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, Guangdong 510301, China; 2. Graduate University of Chinese Academy of Science;1. Key Laboratory of Marine Bio-resources Sustainable Utilization, Key Laboratory of Marine Drug, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, Guangdong 510301, China;1. Key Laboratory of Marine Bio-resources Sustainable Utilization, Key Laboratory of Marine Drug, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, Guangdong 510301, China;1. Key Laboratory of Marine Bio-resources Sustainable Utilization, Key Laboratory of Marine Drug, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, Guangdong 510301, China |
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| Abstract: | As the new scientific field of studying the gene function and interactions of microbial community, metagenomics has largely contributed to the development and utilization of microbial resources, and made breakthrough progress in various fields, such as soil, oceans, human medical, pharmaceutical and so on. Metagenomics provided a novel approach for the discovery of new bioactive substances. Here we discuss some recent progress with emphasis on the opportunities and challenges in metagenomics applications. |
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| Keywords: | Metagenomics Metagenomic library Sequence-based screening Function-based screening Next-generation DNA sequencing |
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