Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. |
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| Authors: | José L Crespo Michael N Hall |
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| Institution: | Division of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland. |
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| Abstract: | TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function. |
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