Determination of hydralazine metabolites: 4-hydrazinophthalazin-1-one and n-acetylhydrazinophthalazin-1-one by gas chromatography and s-triazolo[3,4-a]phthalazine and phthalazinone by high-performance liquid chromatography |
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| Authors: | Vincenzo Facchini John A Timbrell |
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| Institution: | Clinical Toxicology Unit, Department of Clinical Pharmacology, Royal Postgraduate Medical School, London W12 0HS Great Britain |
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| Abstract: | Methods are described for the determination of 4-N-acetylhydrazinophthalazin-1-one, 4-hydrazinophthalazin-1-one, phthalazinone and s-triazolo3,4-a]phthalazine in human urine.4-Hydrazinophthalazin-1-one and 4-N-acetylhydrazinophthalazin-1-one (following acid hydrolysis) are reacted with acetylacetone to give a distinctive pyrazole derivative which can be determined by gas chromatography using a nitrogen-specific detector.Phthalazinone and s-triazolo3,4-a]phthalazine are measured underivatised by high-performance liquid chromatography. |
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