High-performance liquid chromatographic analysis of dipyridamole in plasma and whole blood |
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Authors: | Katherine M Wolfram Thorir D Bjornsson |
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Institution: | Division of Clinical Pharmacology, Departments of Pharmacology and Medicine, Duke University Medical Center, Durham, NC U.S.A. |
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Abstract: | A rapid, sensitive, and specific high-performance liquid chromatographic method is described for the quantitative analysis of dipyridamole in plasma and whole blood. The method involves a single extraction of an alkalinized sample with diethyl ether followed by evaporation of the organic solvent and ion-pair chromatography using fluorescence detection. The lower limit of sensitivity for dipyridamole is 1 ng/ml. Concentrations of dipyridamole between 1 and 500 ng per sample are measured with an average coefficient of variation of 4.5% in plasma and 7.4% in whole blood. |
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