Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase |
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| Authors: | Nencka Radim Votruba Ivan Hrebabecký Hubert Tloust'ová Eva Horská Kveta Masojídková Milena Holý Antonín |
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| Affiliation: | Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic. nencka@uochb.cas.cz |
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| Abstract: | We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases. Bis-uracil conjugates were identified as the most potent inhibitors of TPs in this study. |
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