Studies on the kinetics of the interaction of 7 alpha-hydroxytestosterone with the steroid 5 alpha-reductase |
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| Authors: | J C Mittler |
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| Institution: | 1. Department of Medicine, UMDNJ-New Jersey Medical School, Newark, N.J., USA;2. Medical Service, Veterans Administration Medical Center, East Orange, NJ 07019, USA |
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| Abstract: | Microsomal preparations from adult male rat testicular interstitial cells were incubated with tritiated testosterone. Added 7 alpha-hydroxytestosterone, (7 alpha,17 beta-dihydroxy-4-androsten-3-one), at levels which appear to exist in the adult testis, inhibited production of labelled 5 alpha-reduced steroids in a graded fashion. This interaction is not competitive and occurs only at high substrate levels, such as those found in steroid-producing organs. Relationships to pubertal changes in steroid metabolism are discussed. |
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