Further Studies on 4-Hydroxy-3-Methoxyphenylglycol Oxidation in Humans: Effect of Pool Expansion and Stereochemistry |
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Authors: | Gö ran Må dh |
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Affiliation: | Department of Alcohol and Drug Addiction Research, Karolinska Institutet, Stockholm, Sweden |
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Abstract: | The in vivo oxidation of the norepinephrine metabolite 4-hydroxy-3-methoxyphenylglycol (HMPG) to 4-hydroxy-3-methoxymandelic acid was studied in man with two different doses of deuterium-labeled HMPG and a tracer dose of [14C]HMPG. HMPG oxidation appeared to be dose-dependent with an oxidation of 62-70% for doses below or equal to 2.2 mumol. With the use of a capillary column coated with an optically active phase (Chirasil-Val) and gas chromatography mass-spectrometry the human urinary excretions of the two stereoisomers of deuterium-labelled HMPG (free + conjugates) were found to be equal. |
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Keywords: | 4-Hydroxy-3-methoxyphenylglycol Gas chromatography-mass spectrometry Stereoisomers |
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