Lipid changes in central nervous system membranes in experimental allergic encephalomyelitis (EAE) |
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Authors: | Serafina Salvati Lucilla Attorri Annamaria Confaloni Antonella Di Biase |
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Institution: | (1) Neurochemistry Section, Dept. Metabolism and Pathological Biochemistry, Istituto Superiore di Sanità, Viale Regina Elena, 299,00161 Roma, Italy |
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Abstract: | Lipid composition of myelin fractions isolated from Lewis rats during the early stage of the development of experimental allergic encephalomyelitis (EAE) were determined by high-performance thin layer chromatography (HPTLC). When comparing the myelin fractions of EAE-affected animals with those of controls, the main differences were observed in the light fraction, where a decrease in the percentage of phospholipids (PH) relative to the total lipids was observed. These findings give further support that the light myelin fraction being the most sensitive at the onset of clinical symptoms must play a key role in demyelinating process.Abbreviations used EAE
experimental allergic encephalomyelitis
- PH
phospholipids
- CH
cholesterol
- GL
galactolipid
- PE
phosphatidylethanolamine
- SPM
sphingomyelin
- PC
phosphatidylcholine
- PS
phosphatidylserine
- PI
phosphatidylinositol
- CB
cerebroside
- CB-OH
hydroxy-cerebroside
- SULF
sulfatides
- BP
basic proteins |
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Keywords: | Myelin EAE CNS rat |
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