| 慢性乙型肝炎肝细胞凋亡与肝脏微循环障碍的关系研究 |
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| 引用本文： | 丁体龙,马勇,沈烈,张文学,于莉.慢性乙型肝炎肝细胞凋亡与肝脏微循环障碍的关系研究[J].中国微生态学杂志,2012,24(1):37-39. |
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| 作者姓名： | 丁体龙 马勇 沈烈 张文学 于莉 |
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| 作者单位： | 解放军第一二三医院南京军区肝病中心,安徽蚌埠,233015 |
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| 基金项目： | 南京军区医药卫生科研基金资助(10MA037) |
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| 摘 要： | 目的研究慢性乙型肝炎肝细胞凋亡与肝脏微循环障碍的关系。方法采用TUNEL法检测肝细胞的凋亡率，同时采用透射电镜观察肝细胞超微结构的变化和肝窦微循环结构的改变。结果慢性乙型肝炎肝细胞凋亡率显著增加，细胞膜皱缩并分裂成多个凋亡小体，肝窦内皮细胞窗孔减小减少并伴有狄氏腔胶原沉积和基底膜形成，同时可发现WP小体。结论慢性乙型肝炎肝细胞凋亡是肝脏微循环障碍的重要促进因素。
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| 关 键 词： | 慢性乙型肝炎 细胞凋亡 微循环障碍 |
The relationship between hepatocyte apoptosis and liver microcirculation disturbance |
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| DING Ti-long
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MA Yong
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SHEN Lie
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ZHANG Wen-xue
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YU Li.The relationship between hepatocyte apoptosis and liver microcirculation disturbance[J].Chinese Journal of Microecology,2012,24(1):37-39. |
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| Authors: | DING Ti-long MA Yong SHEN Lie ZHANG Wen-xue YU Li |
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| Institution: | (Center for Liver Disease,Nanjing Military Area Command of Chinese PLA,the 123 Hospital of Chinese PLA,Bengbu,233015,China) |
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| Abstract: | Objective To study the relationship between hepatocyte apoptosis and liver microcirculation disturbance.Method Hepatocyte apoptosis was detected by TUNEL method.Ultrastructure of hepatocyte and the changes of sinus hepaticus microcirculation construction were observed by transmission electron microscope(TEM).Result The rate of hepatocyte apoptosis of patients with chronic hepatitis B increased obviously;hepatocyte cytolemma shrinked and divided to many apoptosis bodies.Decreased sizes and reduced numbers of sinusoidal endothelial cells′(SECs) fenestrae and collagen deposited in Disse space;basal lamina can be found on SECs and WP bodies were found in SECs.Conclusion Hepatocyte apoptosis is an important promoting factor to liver microcirculation disturbance in patients with chronic hepatitis B. |
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| Keywords: | Chronic hepatitis B Apoptosis Microcirculation disturbance |
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