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NMR Studies of the MDP Conjugates with Amino-Acridine/Acridone Derivatives |
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| Authors: | Dzierzbicka K. Gozdowska M. Sowiński P. Wysocka-Skrzela B. Kołodziejczyk A.M. |
| Affiliation: | (1) Department of Organic Chemistry, Technical University of Gdańsk, PL-80-952 Gdańsk, Poland;(2) Laboratory of NMR, Technical University of Gdańsk, PL-80-952 Gdańsk, Poland;(3) Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, PL-80-952 Gdańsk, Poland |
| Abstract: | Summary 1H and13C NMR studies allowed us to determine the structure of anticancer active MDP analogs modified at the C-terminus with amino-acridine/acridone derivatives. The products contain an isoglutamine residue without contamination by their isomers containing a glutamine residue as could be expected based on the literature data. |
| Keywords: | amino-acridine amino-acridone anticancer activity MDP muramyl peptide NMR |
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