New 9,19-cycloartenol glycosides isolated from the roots of Cimicifuga simplex and their anti-inflammatory effects |
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| Institution: | 1. Key Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China;2. Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90025, USA;3. The University of Sydney, NSW 2006, Australia;1. Experimental Physics Department, Ural Federal University, 19 Mira Street, Yekaterinburg 620002, Russia;2. Institute of Physics, University of Tartu, 14c Ravila Street, Tartu 50411, Estonia;1. Institute of Ecological Soil Science, M.V. Lomonosov Moscow State University, Leninskie Goru, MSU, 119992 Moscow, Russian Federation;2. Dokuchaev Soil Institute, Russian Academy of Science, Pyzhevski lane, 7, 109017 Moscow Russia;3. Eurasian Center for Food Security, M.V. Lomonosov Moscow State University, Leninskie Goru, MSU, 119992 Moscow, Russian Federation;4. Institute of Geography, Russian Academy of Sciences, Russian Federation;1. Roseman University of Health Sciences, College of Pharmacy, 10920 South River Front Parkway, South Jordan, UT 84095, USA;2. University of Utah, College of Pharmacy, Department of Pharmacology and Toxicology, Salt Lake City, UT 84112, USA |
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| Abstract: | Two new cycloartenol triterpene saponins, 3β,16α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24R,25-epoxy-cycloartane-3-O-β-d-galactopyranoside (1), 3β,16α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24R,25-epoxy-cycloartane-7-ene-3-O-β-d-xylopyranoside (2), were isolated from the ethyl acetate soluble fraction of the roots of Cimicifuga simplex Wormsk. Their structures were established by detailed spectroscopic analysis, including extensive 2D NMR data. Their anti-proinflammatory activities were also carried out by LPS-stimulated IL-6, IL-23 and TNF-α genes expression in RAW cells in vitro using Q-PCR method. |
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| Keywords: | 16 22-Cyclo-23-ketone type of cycloartane glycosides Anti-inflammatory effect in vitro |
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