Some non-conventional biomolecular targets for diamidines. A short survey |
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| Affiliation: | 1. Xavier University of Louisiana, Department of Basic Pharmaceutical Science, College of Pharmacy, 1 Drexel Drive, New Orleans, LA 70125, USA;2. University of Mons-UMONS, Laboratory of Organic Chemistry, 23 place du parc, 7000 Mons, Belgium;1. Istituto di Biochimica delle Proteine – CNR, Via P. Castellino 111, 80131 Napoli, Italy;2. Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy;3. Department of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia;4. Università degli Studi di Firenze, Polo Scientifico, Dipartimento NEIROFABA;Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Firenze), Italy;1. Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA;2. UMR-S1172—Jean-Pierre Aubert Research Centre (JPARC), INSERM—University of Lille and Centre Hospitalier of Lille, Institut pour la Recherche sur le Cancer de Lille, Place de Verdun, F-59045 Lille Cedex, France;1. School of Electronic and Electrical Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, South Korea;2. Research & Development Center, Amkor Technology Korea Inc., Seoul 133-703, South Korea;3. Materials & Devices Lab, Corporate R&D Institute, Samsung Electro-Mechanics Co. Ltd., Suwon, Gyeonggi 443-743, South Korea;4. Department of Chemistry, Soongsil University, Seoul 156-743, South Korea;1. Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, Paraná, Brazil;2. Departamento de Química, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro, Brazil;3. Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil |
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| Abstract: | Increasing the affinity of diamidines for AT-rich regions of DNA has long been an important goal of medicinal chemists who wanted to improve the antiparasitic and antifungal properties of that class of derivatives. In recent years it was demonstrated that diamidines could interfere with many other biomolecular targets including ion channels as well as enzymes and modulate some RNA–protein, DNA–protein, and protein–protein interactions. It is therefore not surprising that diamidines now emerge as novel potential drug candidates for the treatment of various diseases, i.a. neurodegenerative disorders, acidosis-related pathological conditions, hypertension, thrombosis, type 2 diabetes, myotonic dystrophy, and cancers.A summary of the most striking results obtained to date in those domains is presented is this review. |
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| Keywords: | Amidines Enzymes Ions channels Nucleic acid–protein interactions Protein–protein interactions |
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