Antifungal activity of alkyl gallates against plant pathogenic fungi |
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| Affiliation: | 1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;2. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany;3. Department of Organic Chemistry, Higher Teachers’ Training College, University of Yaounde I., PO Box 47, Yaounde, Cameroon;4. Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia;5. Institute of Inorganic and Structural Chemistry, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany;1. College of Biochemical Engineering, Anhui Polytechnic University, 241000 Wuhu, China;2. Key Lab of Ion Beam Bioengineering, Chinese Academy of Science, 230031 Hefei, China |
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| Abstract: | The antifungal activity of alkyl gallates against plant pathogenic fungi was evaluated. All of the fungi tested in this study were susceptible to some alkyl gallates, and the effect of linear alkyl gallates against plant pathogenic fungi was similar to the previously reported effects against Gram-negative and Gram-positive bacteria. We found that branched alkyl gallates showed stronger activity than did linear alkyl gallates with similar log P values. In addition, the antifungal activity of alkyl gallates was correlated with gallate-induced inhibition of the activity of mitochondrial complex II. The antifungal activity of alkyl gallates likely originates, at least in part, from their ability to inhibit the membrane respiratory chain. |
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| Keywords: | Drug design Gallic acid Structure–activity relationship study |
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