Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner |
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Affiliation: | 1. Modeling of Biological Processes, BioQuant, COS Heidelberg, University of Heidelberg, Heidelberg, Germany;2. Institute of Immunology, University of Heidelberg, Heidelberg, Germany |
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Abstract: | Photo-induced C1′ hydrogen abstraction of 5-fluoro-2′-deoxyuridine was adopted as the key reaction for releasing 5-fluorouracil (5-FU) anticancer drug from oligonucleotide strands. After photoirradiation following 5-FU release, anticancer activity was expected. We demonstrated that oligonucleotide tetramer, d(AFUIUA), can release 5-FU under physiological conditions in a photo-responsive manner thorough photo-induced C1′ hydrogen abstraction, and that the 5-FU released from d(AFUIUA) having a phosphorothioate backbone clearly suppresses the proliferation of HeLa cells in a photo-responsive manner. |
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Keywords: | 5-Fluorouracil Prodrug Photoirradiation Cancer cells |
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