Naturally occurring polyphenolic inhibitors of amyloid beta aggregation |
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Institution: | 1. Department of Pharmacy, CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples “Federico II”, 80134 Naples, Italy;2. Analytical Chemistry for the Environment and CeSMA (Advanced Metrologic Service Center), University of Naples “Federico II”, Corso Nicolangelo Protopisani, 80146 Naples, Italy;3. Institute of Crystallography (IC), National Research Council, 70125, Bari, Italy |
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Abstract: | Alzheimer’s disease is the most common neurodegenerative disease and is one of the main causes of death in developed countries. Consumption of foods rich in polyphenolics is strongly correlated with reduced incidence of Alzheimer’s disease. Our study has investigated the biological activity of previously untested polyphenolic compounds in preventing amyloid β aggregation. The anti-aggregatory potential of these compounds was assessed using the Thioflavin-T assay, transmission electron microscopy, dynamic light scattering and size exclusion chromatography. Two structurally related compounds, luteolin and transilitin were identified as potent inhibitors of Aβ fibril formation. Computational docking studies with an X-ray derived oligomeric structure offer a rationale for the inhibitory activity observed and may facilitate development of improved inhibitors of Aβ aggregation and toxicity. |
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Keywords: | Amyloid Polyphenol Flavonoid Flavonol Isoflavone Amyloid-beta peptide |
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