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Recent developments in the discovery of FFA1 receptor agonists as novel oral treatment for type 2 diabetes mellitus
Institution:1. Lead Generation to Candidate Realization, Sanofi Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt, Germany;2. Diabetes Division, Sanofi Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt, Germany;1. College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, South Korea;2. STEMORE Co. Ltd., Incheon, South Korea;3. Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, South Korea;1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa;2. South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa;3. MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Division of Medical Microbiology, University of Cape Town, Rondebosch 7701, South Africa;4. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa;5. Centre for World Health and Medicine, Saint Louis University, USA
Abstract:Despite the availability of established medication for treatment of type 2 diabetes mellitus (T2DM) there still remains a significant unmet need for new effective, oral antidiabetic agents that improve glycemic control while maintaining an excellent safety profile. In this regard the FFA1 receptor has emerged as an attractive target in recent years. Activation of the FFA1 receptor has been shown to not only amplify glucose induced insulin secretion from pancreatic beta cells but also to stimulate incretin secretion from intestinal endocrine cells. The current review highlights on the latest developments and clinical data from evolving research on the potential of FFA1 agonists as effective treatment for T2DM.
Keywords:Type 2 diabetes  Oral antidiabetics  GPR40  FFA1  GPCRs
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