Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt;2. Department of Chemistry, Faculty of Science, Ibb University, Yemen;3. Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt;1. Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt;2. Department of Medicinal Chemistry, Faculty of Pharmacy, El-Minia University, 61519 El-Minia, Egypt;3. Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany;4. Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, 00014 Helsinki, Finland;1. Unité de Recherche de Chimie de l’Environnement et Moléculaire Structurale (CHEMS), Département de Chimie, Université des frères Mentouri-Constantine 1, 25000 Constantine, Algeria;3. Center of Molecular and Materials Modelling, Hasselt University, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium;1. Department of Forest Industrial Engineering, Faculty of Forestry, Kastamonu University, Kastamonu, 37100, Turkey;2. Department of Chemistry, Faculty of Art and Science, Kastamonu University, Kastamonu, 37100, Turkey;3. Biomedical Engineering Department, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, 37100, Turkey;4. Food Engineering Department, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, 37100 Turkey;1. Department of Chemistry, National Institute of Technology, Warangal 506004, Telangana, India;2. Environmental Monitoring &Exposure Assessment (Air) Laboratory, ICMR-NIREH, Bhopal 462 030, MP, India;3. Medicinal Chemistry and Pharmacology Division, CSIR–IICT, Hyderabad 500 007, Telangana, India;4. Division of Microbiology, CSIR−CDRI, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India;5. Department of Chemistry, National Institute of Technology, Calicut 673601, Kerala, India;1. Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, 425405 Maharashtra, India;2. Department of Pharmaceutical Chemistry, H.R. Patel College of Pharmacy, Shirpur, Dhule, 425405 Maharashtra, India;1. Department of Pathophysiology, Medical University of Lublin, Lublin, Poland;2. Isobolographic Analysis Laboratory, Institute of Rural Health, Lublin, Poland;3. Institute of Industrial Organic Chemistry, Warszawa, Poland;4. Department of Chemistry, University of Life Sciences in Lublin, Lublin, Poland |
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| Abstract: | A series of new pyrazolo[3,4-b]pyrazines containing, 1,2,4-oxadiazolyl, thiadiazolyl, imidazothiadiazolyl, thiazolidinonyl, substituents and other different substituents, was synthesized using 1,6-diphenyl-3-methyl-lH-pyrazolo[3,4-b]pyrazine-5-carbonitrile (2) as a starting material. Some of the newly prepared compounds were evaluated for their anticonvulsant activity. Compounds 9a, 13a–d and 14a at a dose of 10 mg/kg showed very significant anticonvulsant activity and increased the latency time of PTZ-induced tonic seizures. Compound 9b showed significant effect. |
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| Keywords: | Oxadiazoles Thiadiazoles Imidazothiadiazoles Thiazolidinones Anticonvulsant activity |
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