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Fluorescent analog of OSW-1 and its cellular localization |
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| Affiliation: | 1. Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jimming Campus, Kaifeng 475004, Henan, China;2. Institute of Behavior and Psychology, Henan University Jimming Campus, Kaifeng 475004, Henan, China |
| Abstract: | OSW-1 is a steroidal saponin, which has emerged as an attractive anticancer agent with highly cancer cell selective activity. A fluorescent analog was prepared from the natural product to analyze its cellular uptake and localization. We found that the fluorescent analog is rapidly internalized into cells and is primarily distributed in endoplasmic reticulum and Golgi apparatus. |
| Keywords: | Steroidal glycoside Fluorescent probe Anticancer agent Cellular uptake Cellular localization |
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